Unique IS-2® is one of five ingredients in Ozenica's Trimfexa® blend. See the full blend and the other four ingredients by clicking below.
A healthy gut is the foundation of a healthy metabolism.
Unique IS-2®: Gut Health & Protein Absorption
Unique IS-2® is a patented strain of Bacillus coagulans — a spore-forming probiotic that is exceptionally stable at room temperature and highly survivable through the digestive tract. Unlike many probiotic strains that lose viability before reaching the gut, Bacillus coagulans germinates in the intestine and establishes effectively with each dose.
Unique IS-2® has been clinically studied for two outcomes particularly relevant to weight management: supporting gut microbiome balance and — critically — increasing the absorption of amino acids and branched-chain amino acids (BCAAs) from dietary protein. Better protein absorption means the body has what it needs to maintain lean muscle during a calorie deficit.
The gut produces a significant portion of the body's GLP-1 and other satiety hormones. Gut health also directly affects how efficiently dietary protein is broken down and absorbed — which in turn affects muscle maintenance. Unique IS-2® pairs directly with DNF-10® in the Trimfexa® blend: one supports fat-preferential weight loss, the other ensures the body has the building blocks to maintain the muscle it keeps. This is the gut-muscle connection most weight loss products completely ignore.
Unique IS-2® in Ozenica®
Specification
Ingredient form
Unique IS-2® (patented Bacillus coagulans strain)
Dose per 2-capsule daily serving
2 billion CFU
Mechanism
Supports gut microbiome balance; studied to increase amino acid and BCAA absorption
Stability
Spore-forming strain — stable at room temperature; no refrigeration required
Patent status
Patented strain — not a generic Bacillus coagulans powder
Frequently Asked Questions
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No. Unique IS-2® is a spore-forming Bacillus coagulans strain, which means it is shelf-stable at room temperature. Store Ozenica in a cool, dry place away from direct sunlight.
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Because gut health and weight management are not separate systems. The gut produces satiety hormones, affects metabolic rate, and determines how efficiently your body uses the protein you eat to maintain muscle. A probiotic that specifically supports protein absorption addresses a foundational piece of the weight management puzzle that most supplements completely overlook.
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Some people experience mild digestive changes in the first week as the probiotic establishes in the gut. This is normal and typically resolves within a few days. Taking Ozenica before a meal (rather than on a completely empty stomach) minimizes any initial adjustment.
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Unique IS-2® is a patented Bacillus coagulans probiotic studied for supporting gut health and improving how the body absorbs amino acids from protein. Better amino acid absorption helps the body make use of dietary protein, which matters for maintaining lean muscle during weight management. It has also been studied for supporting digestion and easing common issues like bloating and irregularity.